Verse 25 marks a breaking point. The subject changes again. This time, Isaiah returns to the prophecies about the Assyrian influence on the Jews and Philistines. Most commentaries interpret this verse as having reference to the time when the Assyrian armies came against Jerusalem and king Hezekiah. At that time the Lord destroyed the host of the Assyrians by a great miracle (2 Kings 19:35). With this interpretation, the yoke which departs from off them is the yoke of the Assyrians coming off the neck of the Jews.