This is a fairly generic verse, and marks time before the next spiritually important event. All we are told is that the "wrath of God is upon the seed of thy brethren". We are left to wonder what the nature of that wrath is. It is undeclared. It may or may not be related to specific events prior to the discovery of the New World. It is most likely that it is a generic indication that all was not perfect, and that bad things happened to those people. Certainly there is enough in the history of the world to support that generality.